# Sources discussed here

> Philadelphia Anti Aging reading list — The Philadelphia Anti Aging reading list: GHRH agonists and antagonists, human cognition, structural brain imaging and metabolic findings.

The experiments have different jobs here. The animal work raises the puzzle; the human studies ask more specific questions about cognition, structure and consequences.

## Agonist and antagonist experiments

The [MIA-690 antagonist paper](https://pubmed.ncbi.nlm.nih.gov/23211425/) and the [MR-409 agonist paper](https://pubmed.ncbi.nlm.nih.gov/41946684/) supply the central disagreement. Both include animal and cell work, with different interventions. The [GHRH review](https://pubmed.ncbi.nlm.nih.gov/39537825/) gives the broader pharmacological context.

## Human studies and the editorial

The [tesamorelin cognition trial](https://pubmed.ncbi.nlm.nih.gov/22869065/) tests an intervention in older adults. The [congenital-deficiency MRI study](https://pubmed.ncbi.nlm.nih.gov/38627331/) compares untreated adults with matched controls. Their differing questions make the pairing productive in my estimation.

For the consequences elsewhere in the body, read the [PEG-conjugated GHRH study](https://pubmed.ncbi.nlm.nih.gov/16061831/) beside the [age-advanced men-and-women study](https://pubmed.ncbi.nlm.nih.gov/9141536/). The [secretagogue editorial](https://pubmed.ncbi.nlm.nih.gov/18981489/) supplies an objection to the broader anti-aging use.

## References

[1] Beneficial effects of novel antagonists of GHRH in different models of Alzheimer's disease. https://pubmed.ncbi.nlm.nih.gov/23211425/
[2] Growth hormone-releasing hormone attenuates amyloid deposition and neuroinflammation in Alzheimer's disease models. https://pubmed.ncbi.nlm.nih.gov/41946684/
[3] Effects of growth hormone-releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial https://pubmed.ncbi.nlm.nih.gov/22869065/
[4] Brain morphometry and estimation of aging brain in subjects with congenital untreated isolated GH deficiency. https://pubmed.ncbi.nlm.nih.gov/38627331/
[5] Polyethylene glycol-conjugated growth hormone-releasing hormone is long acting and stimulates GH in healthy young and elderly subjects. https://pubmed.ncbi.nlm.nih.gov/16061831/
[6] Endocrine and metabolic effects of long-term administration of [Nle27]growth hormone-releasing hormone-(1-29)-NH2 in age-advanced men and women. https://pubmed.ncbi.nlm.nih.gov/9141536/
[7] Use of growth hormone secretagogues to prevent or treat the effects of aging: not yet ready for prime time https://pubmed.ncbi.nlm.nih.gov/18981489/
[8] Growth hormone-releasing hormone and its analogues in health and disease https://pubmed.ncbi.nlm.nih.gov/39537825/

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Philadelphia Anti Aging brings my objections and enthusiasms to published research on the aging mind; it runs no business and gives no medical advice.